albumin - publications

Predict more albumin - ligand interactions now!


1. Syst Biol Reprod Med. 2012 Apr 20. [Epub ahead of print]

The influence of the redox state of follicular fluid albumin on the viability of
aspirated human oocytes.

Otsuki J, Nagai Y, Matsuyama Y, Terada T, Era S.

Nagai Clinic, Kamihikona Misato, Saitama , Japan.

A number of reports have suggested that the oxidative state of human albumin in
serum and in some body fluids is associated with cell damage. However there are
no reports on the redox state of human follicular fluid (FF) and its influence on
oocyte viability. The aim of this study was to examine the relationship between
the redox state of FF and serum on oocyte viability. The cytoplasmic condition of
oocytes was evaluated microscopically at collection in 117 women. Deteriorating
oocytes were recognized by degenerative changes in their cytoplasm. The redox
state of FFs that yielded degenerated oocytes was evaluated and compared with
fluids containing normal oocytes. The redox state of the corresponding FF and
serum, at the time of oocyte retrieval, was analyzed by high performance liquid
chromatography. The redox state of FF that contained degenerated oocytes was
found to have a significantly elevated oxidized state compared with the FFs that
yielded normal oocytes. Also the albumin in the FF of patients was found to be
predominantly in the reduced state compared with that in their serum at the time
of oocyte retrieval. In addition, increasing age and endometriosis were found to
shift the redox of serum to the oxidative state. We propose that the reduced
state of albumin in FF may play an important role in protecting oocytes from
oxidative damage.

PMID: 22515725 [PubMed - as supplied by publisher]