albumin - publications

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1. Spectrochim Acta A Mol Biomol Spectrosc. 2012 Jan 10;89C:270-275. [Epub ahead of
print]

The influence of fatty acids on theophylline binding to human serum albumin.
Comparative fluorescence study.

Maciążek-Jurczyk M, Sułkowska A, Bojko B, Równicka-Zubik J, Szkudlarek-Haśnik A,
Zubik-Skupień I, Góra A, Dubas M, Korzonek-Szlacheta I, Wielkoszyński T,
Zurawiński W, Sosada K.

Department of Physical Pharmacy, Medical University of Silesia, Jagiellońska 4,
41-200 Sosnowiec, Poland.

Theophylline, popular diuretic, is used to treat asthma and bronchospasm. In
blood it forms complexes with albumin, which is also the main transporter of
fatty acids. The aim of the present study was to describe the influence of fatty
acids (FA) on binding of theophylline (Th) to human serum albumin (HSA) in the
high affinity binding sites. Binding parameters have been obtained on the basis
of the fluorescence analysis. The data obtained for the complex of Th and natural
human serum albumin (nHSA) obtained from blood of obese patients qualified for
surgical removal of stomach was compared with our previous studies on the
influence of FA on the complex of Th and commercially available defatted human
serum albumin (dHSA).

Copyright © 2011 Elsevier B.V. All rights reserved.

PMID: 22286055 [PubMed - as supplied by publisher]