albumin - publications

Predict more albumin - ligand interactions now!


1. Drug Metab Dispos. 2012 May 14. [Epub ahead of print]

The Increased Cellular Uptake and Biliary Excretion of Curcumin by Quercetin: A
Possible Role of Albumin Binding Interaction.

Kim HG, Lee JH, Lee SJ, Oh JH, Shin E, Jang YP, Lee YJ.

1 1Department of Life and Nanopharmaceutical Sciences, Kyung Hee University;

Curcumin and quercetin are natural compounds with a wide spectrum of activities,
including antioxidant and anticancer activities. In this study, the combined
effect of the 2 compounds was investigated, with special emphasis on the
pharmacokinetics of curcumin by the quercetin-induced changes in the
albumin-binding of curcumin. We evaluated the effect of quercetin on the binding
of curcumin to albumin and on the uptake of curcumin into the cells of the human
colon carcinoma cell line WiDr. Additionally, we also investigated the changes in
the in vivo pharmacokinetics of curcumin and curcumin sulfate, major metabolite
of curcumin by co-administered with quercetin. We found that quercetin inhibited
the binding of curcumin to albumin and increased the uptake of curcumin into WiDr
cells, the human colon carcinoma cell. The quercetin-induced increased uptake
(1.6-fold) of curcumin into WiDr cells was also confirmed by an ex vivo study.
The in vivo pharmacokinetics of curcumin showed obvious changes when it was
co-administered with quercetin, with the significantly lower plasma concentration
and greater biliary excretion of curcumin and curcumin sulfate. The present study
suggests that quercetin could enhance the cellular uptake of curcumin and
modulate in vivo pharmacokinetics of curcumin and it could be related with
albumin binding interaction.

PMID: 22584252 [PubMed - as supplied by publisher]