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The glycated albumin to glycated haemoglobin ratio increases along with the fibrosis stage in non-alcoholic steatohepatitis.


Ann Clin Biochem. 2012 Jun 19;


Authors: Bando Y, Kanehara H, Aoki K, Toya D, Notsumata K, Tanaka N, Enomoto H, Nishiguchi SH, Nakasho K, Nakamura H, Kasayama S, Koga M


Abstract

BACKGROUND: We previously reported that the indicator of glycaemic control, glycated albumin (GA) levels, are low in relation to glycaemia in patients with high alanine aminotransferase (ALT) levels in non-alcoholic fatty liver disease because of chronic inflammation, and that the GA/glycated haemoglobin ratio (G/H ratio) is inversely correlated with hepatic function in patients with chronic liver disease. The severity of liver fibrosis is known to be a good indicator for surveillance, and for determining the prognosis and optimal treatment of non-alcoholic steatohepatitis (NASH). In this study, we aimed to investigate the clinical usefulness of measuring the G/H ratio for predicting the severity of liver fibrosis in patients with NASH. METHODS: The study subjects were 36 patients with histologically diagnosed NASH (19 men, 17 women; mean age54.8 ± 12.2 years, body mass index 28.3 ± 5.0 kg/m(2)). The relationships of the G/H ratio to hepatic function tests and fibrosis stage in the liver were investigated. RESULTS: The G/H ratio in patients with NASH was inversely correlated with ALT (P < 0.001) and platelet count (P < 0.0001). Furthermore, the G/H ratio was positively correlated with the fibrosis stage in liver (P = 0.003). CONCLUSIONS: These results suggest that the G/H ratio increases along with the fibrosis stage in patients with NASH.

PMID: 22715293 [PubMed - as supplied by publisher]