albumin - publications

Predict more albumin - ligand interactions now!

1. J Biomed Mater Res A. 2012 Mar 6. doi: 10.1002/jbm.a.34051. [Epub ahead of print]

Tamoxifen-loaded thiolated alginate-albumin nanoparticles as antitumoral drug
delivery systems.

Martínez A, Benito-Miguel M, Iglesias I, Teijón JM, Blanco MD.

Group of Polymeric Materials for the Controlled Release of Bioactive Compounds in
Biomedicine, Departamento de Farmacología, Facultad de Farmacia, Universidad
Complutense de Madrid, Spain.

Nanoparticles based on disulfide bond reduced bovine serum albumin and thiolated
alginate (alginate-cysteine conjugate) have been prepared by coacervation method
and have been loaded with tamoxifen (TMX). The TMX load into the nanoparticles
was optimized (4-6 μg/mg NP) by freeze-drying the systems before the loading
procedure. Maximum TMX release (45-52%) took place between 2 and 25 h.
Cytotoxicity of unloaded nanoparticles in MCF-7 and HeLa cells was not observed,
although a small decrease in viability took place at very high concentration.
Cell uptake of nanoparticles occurred in both cell types and the presence of
polysaccharide in the nanoparticle composition allowed a better interaction with
cells. The administration of 10 μM TMX by TMX-nanoparticles was effective in both
cellular lines, and the effect of the drug-loaded systems on MCF-7 cell cycle
showed the efficacy of the TMX-loaded nanoparticles. © 2012 Wiley Periodicals,
Inc. J Biomed Mater Res Part A, 2012.

Copyright © 2012 Wiley Periodicals, Inc.

PMID: 22396108 [PubMed - as supplied by publisher]