albumin - publications
Predict more albumin - ligand interactions now!
1. J Med Chem. 2012 Apr 19. [Epub ahead of print]Synthesis and Antitumor Efficacy of a -Glucuronidase-Responsive Albumin-Binding Prodrug of Doxorubicin.Legigan T, Clarhaut J, Renoux B, Tranoy-Opalinski I, Monvoisin A, Berjeaud JM,Guilhot F, Papot S.In this paper we describe the synthesis and biological evaluation of the first-glucuronidase-responsive albumin-binding prodrug designed for the selectivedelivery of doxorubicin at the tumor site. This prodrug leads to superiorantitumor efficacy in mice compared to HMR 1826, a well-known glucuronide prodrugof doxorubicin which can not bind covalently to circulating albumin. Furthermore,this compound inhibits tumor growth in a similar manner to doxorubicin whilstavoiding side effects induced by the free drug.PMID: 22515366 [PubMed - as supplied by publisher]