albumin - publications

Predict more albumin - ligand interactions now!

1. J Biomed Nanotechnol. 2012 Feb;8(1):182-9.

Successful strategy for targeting the central nervous system using magnetic
albumin nanospheres.

Cintra e Silva Dde O, Estevanato LL, Simioni AR, Rodrigues MM, Lacava BM, Lacava
ZG, Tedesco AC, Morais PC, Báo SN.

University of Brasília, Institute of Biological Sciences, Department of Cell
Biology, Laboratory of Electronic Microscopy, Brasília DF, 70919-970, Brazil.

This study reports on the successful use of magnetic albumin nanosphere (MAN),
consisting of maghemite nanoparticles hosted by albumin-based nanosphere, to
target different sites within the central nervous system (CNS). Ultrastructural
analysis by transmission electron microscopy (TEM) of the material collected from
the mice was performed in the time window of 30 minutes up to 30 days after
administration. Evidence found that the administered MAN was initially
internalized and transported by erythrocytes across the blood-brain-barrier and
transferred to glial cells and neuropils before internalization by neurons,
mainly in the cerebellum. We hypothesize that the efficiency of MAN in crossing
the BBB with no pathological alterations is due to the synergistic effect of its
two main components, the iron-based nanosized particles and the hosting
albumin-based nanospheres. We found that the MAN in targeting the CNS represents
an important step towards the design of nanosized materials for clinical and
diagnostic applications.

PMID: 22515106 [PubMed - in process]