albumin - publications

Predict more albumin - ligand interactions now!


1. Chem Res Toxicol. 2012 Apr 6. [Epub ahead of print]

Structural Evidence of Perfluorooctane Sulfonate Transport by Human Serum
Albumin.

Luo Z, Shi X, Hu Q, Zhao B, Huang M.

Perfluorooctane sulfonate (PFOS) is a man-made fluorosurfactant and globally
persistent organic pollutant. PFOS is mainly distributed in blood with a long
half-life for elimination. PFOS was found mainly bound to human serum albumin
(HSA) in plasma, the most abundant protein in human blood plasma, which
transports variety of endogenous and exogenous ligands. However, the structural
basis of such binding remains unclear. Here we report the crystal structure of
HSA-PFOS complex, and show that PFOS binds to HSA at a ratio of 2:1. In addition,
PFOS binding renders the HSA structure more compact. Our results provide a
structural mechanism to understand the retention of surfactants in human serum.

PMID: 22482699 [PubMed - as supplied by publisher]