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Spectroscopic investigation on the intermolecular interaction between N-confused porphyrins-(3-methylisoxazole) diad and bovine serum albumin.


Spectrochim Acta A Mol Biomol Spectrosc. 2012 Sep 21;99C:116-121


Authors: Lu S, Yu X, Yang Y, Li X


Abstract

The intermolecular interaction between N-confused porphyrins-(3-methylisoxazole) diad (NCP-(3-methylisoxazole)) and bovine serum albumin (BSA) has been investigated through fluorescence and ultraviolet spectroscopy at different temperatures under imitated physiological conditions. The results showed that the fluorescence of BSA was quenched by NCP-(3-methylisoxazole) through a combined quenching procedure. The characteristics of NCP-(3-methylisoxazole)⋯BSA interaction (including interaction nature, interaction conformation, binding constants, binding sites, binding distance, thermodynamic parameters, etc.) and the effect of metal ions (Cu(2+), Mg(2+), Ca(2+), and Ni(2+)) upon the NCP-(3-methylisoxazole)⋯BSA interaction have been detailed studied.

PMID: 23063853 [PubMed - as supplied by publisher]