albumin - publications

Predict more albumin - ligand interactions now!

1. Spectrochim Acta A Mol Biomol Spectrosc. 2012 Apr 4;94C:228-234. [Epub ahead of

Spectroscopic analyses on sonocatalytic damage to bovine serum albumin (BSA)
induced by ZnO/hydroxylapatite (ZnO/HA) composite under ultrasonic irradiation.

Wang Z, Li Y, Wang J, Zou M, Gao J, Kong Y, Li K, Han G.

College of Chemistry, Liaoning University, Shenyang 110036, PR China.

ZnO/hydroxylapatite (ZnO/HA) composite with HA molar content of 6.0% was prepared
by the method of precipitation and heat-treated at 500°C for 40min and was
characterized by powder X-ray diffraction (XRD). The sonocatalytic activities of
ZnO/HA composite was carried out through the damage of bovine serum albumin (BSA)
in aqueous solution. Furthermore, the effects of several factors on the damage of
BSA molecules were evaluated by means of UV-vis and fluorescence spectra.
Experimental results indicated that the damage degree of BSA aggravated with the
increase of ultrasonic irradiation time, irradiation power and ZnO/HA addition
amount, but weakened with the increase of solution acidity and ionic strength. In
addition, the damage site to BSA was also studied by synchronous fluorescence
technology and the damage site was mainly at tryptophan (Trp) residue. This paper
provides a valuable reference for driving sonocatalytic method to treat tumor in
clinic application.

Copyright © 2012 Elsevier B.V. All rights reserved.

PMID: 22522300 [PubMed - as supplied by publisher]