albumin - publications

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1. Acta Med Iran. 2012 Mar;50(3):197-202.

Significance of albumin and C-reactive protein variations in 300 end stage renal
disease patients in tehran university of medical sciences hospitals during year
2010.

Dashti N, Einollahi N, Nabatchian F, Moradi Sarabi M, Zarebavani M.

Department of Clinical Laboratory Sciences, School of Allied Medical Sciences,
Tehran University of Medical Sciences, Tehran, Iran.

Protein- energy malnutrition, wasting and inflammation are frequent complication
among patients with end-stage renal disease (ESRD). Malnutrition is associated
with cardiac co-morbidity, inflammation and poor survival in ESRD patients. Serum
albumin is a well-known marker of nutrition in ESRD patients. Serum albumin is
still the most commonly used nutritional marker in ESRD patients. C-reactive
protein (CRP), the major acute phase response (APR) protein is elevated in these
patients. High CRP levels are linked to the degree of atherosclerosis in
coronary, peripheral, and extracranial brain arteries. The aim of the present
study was to investigate nutritional factor (albumin) and CRP levels in ESRD
patients. In this cross- sectional study a total of 300 patients who had ESRD and
had been on hemodialysis treatment for at least 6 months were selected. The
laboratory tests consisted of measurement of CRP and albumin using high sensitive
ELISA kits. The study patients included 157 males (52.3%) and 143 females (47.7%)
with average age of 41.5±14.3 years. Mean CRP level was 7.96 mg/ dl (±1.52), mean
serum albumin was 4.07 g/dl (±0.19).Of 300 patients, 21 died (7%). These were
patients with serum albumin <4 g/dl and CRP>9.5 mg/dl. This study showed that low
albumin and high CRP levels are the main predictors for death. There was a
significant difference between CRP and albumin levels in ESRD patients
(P<0.0001). Measuring CRP as a marker of inflammation can be helpful in managing
these patients.

PMID: 22418989 [PubMed - in process]