albumin - publications

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1. J Reprod Med. 2012 Jan-Feb;57(1-2):49-52.

Serum ischemia modified albumin levels in pregnancies with neural tube defects.

Güzelmansur I, Ustün Y, Engin-Ustün Y, Oztürk O, Yaman H.

Department of Radiology, Antakya Government Hospital, Ankara, Turkey.

OBJECTIVE: To evaluate ischemia-modified albumin (IMA) in women who had been
pregnant with a child suffering from neural tube defect.
STUDY DESIGN: Samples from 50 women who had been pregnant with an affected child
(25 spina bifida, 25 anencephaly) and 25 controls matched for age, gestational
age, and body mass index were studied. We measured serum IMA by enzyme-linked
immunosorbent assay.
RESULTS: Serum IMA was significantly higher in the study group compared to normal
pregnancies (p < 0.05). The area under the receiver operating curve was 0.858 for
IMA (95% CI, 0.769-0.947), whereas the optimal threshold value of IMA to
discriminate between affected children and controls was 0.409 (sensitivity 88%,
specificity 80%). The risk for increased IMA in mothers who have conceived a
fetus with neural tube defect is 24.5 times higher than in the control group (rr
= 24.5, 6.9-86.9, 95% CI) (p = 0.001).
CONCLUSION: This study indicates that serum IMA in women who have conceived a
fetus with neural tube defect is significantly higher than that in normal
pregnant women.

PMID: 22324268 [PubMed - in process]