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Serum Albumin Level is a Notable Profiling Factor for non-HBV-, non-HCV-related Hepatocellular Carcinoma: A Data-mining Analysis.

Hepatol Res. 2013 Jul 2;

Authors: Yamada S, Kawaguchi A, Kawaguchi T, Fukushima N, Kuromatsu R, Sumie S, Takata A, Nakano M, Satani M, Tonan T, Fujimoto K, Shima H, Kakuma T, Torimura T, Charlton MR, Sata M


BACKGROUND: Various factors are underlying for the onset of non-hepatitis B virus/non-hepatitis C virus-related hepatocellular carcinoma (NBNC-HCC). We aimed to investigate the independent risk factors and profiles associated with NBNC-HCC using a data-mining technique.

METHODS: We conducted a case-control study and enrolled 223 NBNC-HCC patients and 669 controls from a health checkup database (n=176,886). Multivariate analysis, random forest analysis, and a decision-tree algorithm were employed to examine the independent risk factors, factors distinguishing between the case and control groups, and to identify profiles for the incidence of NBNC-HCC, respectively.

RESULTS: In multivariate analysis, besides gamma-glutamyl transpeptidase (GGT) levels and the Brinkman index, albumin level was an independent negative risk factor for the incidence of NBNC-HCC (OR 0.67; 95% CI 0.60-0.70; P < 0.0001). In random forest analysis, serum albumin level was the highest-ranked variable for distinguishing between the case and control groups (98 variable importance). A decision-tree algorithm was created for albumin and GGT levels, the aspartate aminotransferase to platelet ratio index (APRI), and the Brinkman index. The serum albumin level was selected as the initial split variable, and 82.5% of the subjects with albumin levels < 4.01 g/dL were found to have NBNC-HCC.

CONCLUSIONS: Data-mining analysis revealed that serum albumin level is an independent risk factor and the most distinguishable factor associated with the incidence of NBNC-HCC. Furthermore, we created a NBNC-HCC profile consisting of albumin and GGT levels, the APRI, and the Brinkman index. This profile could be used in the screening strategy for NBNC-HCC.

PMID: 23819517 [PubMed - as supplied by publisher]