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1. PLoS One. 2012;7(5):e36306. Epub 2012 May 11.

rs4919510 in hsa-mir-608 Is Associated with Outcome but Not Risk of Colorectal

Ryan BM, McClary AC, Valeri N, Robinson D, Paone A, Bowman ED, Robles AI, Croce
C, Harris CC.

Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer
Institute, Bethesda, Maryland, United States of America.

BACKGROUND: Colorectal cancer is the third most incident cancer and cause of
cancer-related death in the United States. MicroRNAs, a class of small non-coding
RNAs, have been implicated in the pathogenesis and prognosis of colorectal
cancer, although few studies have examined the relationship between germline
mutation in the microRNAs with risk and prognosis. We therefore investigated the
association between a SNP in hsa-mir-608, which lies within the 10q24 locus, and
colorectal cancer.
METHODS AND RESULTS: A cohort consisting of 245 cases and 446 controls was
genotyped for rs4919510. The frequency of the GG genotype was significantly
higher in African Americans (15%) compared to Caucasians (3%) controls. There was
no significant association between rs4919510 and colorectal cancer risk (African
American: OR(GG vs. CC) 0.89 [95% CI, 0.41-1.80]) (Caucasian: OR(GG vs. CC) 1.76,
([95% CI, 0.48-6.39]). However, we did observe an association with survival. The
GG genotype was associated with an increased risk of death in Caucasians (HR(GG
vs. CC) 3.54 ([95% CI, 1.38-9.12]) and with a reduced risk of death in African
Americans (HR(GG vs. CC) 0.36 ([95% CI 0.12-1.07).
CONCLUSIONS: These results suggest that rs4910510 may be associated with
colorectal cancer survival in a manner that is dependent on race.

PMCID: PMC3350523
PMID: 22606253 [PubMed - in process]