albumin - publications

Predict more albumin - ligand interactions now!

1. Bioorg Khim. 2011 Sep-Oct;37(5):718-20.

[Role of the medium acidity in the complexes formation of pyropheophorbide a with
albumin and lipoproteins].

[Article in Russian]

[No authors listed]

The spectral characteristics of the photosensitizer pyropheophorbide a (PPP)
complexes with its carriers, that is, serum albumin and low density lipoproteins,
were investigated in aqueous solutions at pH 7.4 and 5.0. The acidic pH had no
effect on the quantitative parameters of PPP binding to lipoproteins but reduces
its affinity for albumin. Differential role of acidification in the binding of
PPP to biomacromolecules should be considered in the design of PPP-based drugs
given that pH is frequently lowered in the sites of the disease.

PMID: 22332371 [PubMed - in process]