albumin - publications

Predict more albumin - ligand interactions now!


1. Antioxid Redox Signal. 2012 May 16. [Epub ahead of print]

Redox albuminomics: oxidized albumin in human diseases.

Colombo G, Clerici M, Giustarini D, Rossi R, Milzani A, Dalle-Donne I.

University of Milan, Department of Life Sciences, Milan, Italy;
graziano.colombo@unimi.it.

Significance: Albumin is the major contributor to colloid oncotic pressure and
also serves as an important carrier protein of many endogenous and exogenous
molecules throughout the body. In blood and extravascular fluids, albumin is
susceptible to different oxidative modifications, especially thiol oxidation and
carbonylation. Because of its metal-binding properties and the redox properties
of its Cys34 thiol, albumin displays an important anti-oxidant activity. As
albumin is the predominant protein in most body fluids, its Cys34 represents the
largest fraction of free thiols within body fluids. Recent Advances: Evidence
that albumin oxidation takes place in vivo has been reported only recently.
Different redox proteomic, mass spectrometric, and chromatographic techniques
have shown albumin redox modifications in various human pathophysiological
conditions. As a whole, most data here presented demonstrate that massive albumin
oxidation occurs in vivo in different biological fluids and, to some extent, that
this process is correlated to organ dysfunction. Critical Issues: Recent reports
suggest that the albumin redox state may serve as a global biomarker for the
redox state in the body in various human diseases. However, further study is
required in order to elucidate the exact relationship between albumin oxidation
and pathology. In addition, it is unknown if some albumin oxidized forms may also
have diagnostic uses. Future Directions: Application of specific redox proteomics
techniques for the characterization of oxidized albumin forms in screening
studies is required. A further challenge will be to analyze how these oxidative
albumin modifications are related to real impact to the body.

PMID: 22587567 [PubMed - as supplied by publisher]