albumin - publications

Predict more albumin - ligand interactions now!

1. J Phys Chem B. 2012 Apr 2. [Epub ahead of print]

Protein and Water Dynamics in Bovine Serum Albumin-Water Mixtures Over Wide
Ranges of Composition.

Panagopoulou A, Kyritsis A, Shinyashiki N, Pissis P.

Dielectric dynamic behavior of bovine serum albumin (BSA)-water mixtures over
wide ranges of water fractions, from dry protein until 40 wt % in water, was
studied through dielectric relaxation spectroscopy (DRS). The α relaxation
associated with the glass transition of the hydrated system was identified. The
evolution of the low temperature dielectric relaxation of small polar groups of
the protein surface with hydration level, results in the enhancement of
dielectric response and the decrease of relaxation times, until a critical water
fraction, which corresponds to the percolation threshold for protonic
conductivity. For water fractions higher than the critical one, the position of
the secondary ν relaxation of water saturates in the Arrhenius diagram, while
contributions originating from water molecules in excess (uncrystallized water or
ice), follow separate relaxation modes slower than the ν relaxation.

PMID: 22469064 [PubMed - as supplied by publisher]