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1. Ann Nutr Metab. 2012 Feb 21;60(2):83-89. [Epub ahead of print]

Plasma Pyridoxal 5'-Phosphate Is Not Associated with Inflammatory and Immune
Responses after Adjusting for Serum Albumin in Patients with Rheumatoid
Arthritis: A Preliminary Study.

Huang SC, Wei JC, Lin PT, Wu DJ, Huang YC.

School of Nutrition, Chung Shan Medical University, Taichung, Taiwan, ROC.

Background/Aims: Plasma pyridoxal 5'-phosphate (PLP) has been shown to be
associated with inflammatory and immune responses.Rheumatoid arthritis (RA) is an
autoimmune and chronic systemic inflammatory disease and patients with RA have
lower plasma PLP levels. We studied the relationship between plasma PLP and
inflammatory or immune responses in patients with RA. Methods: This study was
designed as an observational cross-sectional study. Forty-three patients with RA
were allocated to the adequate (PLP ≥20 nmol/l) (n = 30) or deficient vitamin
B(6) (PLP <20 nmol/l) (n = 13) group according to their fasting plasma PLP
concentration on the day blood was taken. Plasma PLP, inflammatory parameters
[i.e. high-sensitivity CRP (hs-CRP), erythrocyte sedimentation rate,
interleukin-6, tumor necrosis factor-α] and immune parameters (i.e. white blood
cells, total lymphocytes, neutrophils, T lymphocytes, B lymphocytes, T helper
cells and T suppressor cells) were measured. Results: Patients with deficient
plasma PLP concentration were mostly considered to have a systemic inflammatory
status (hs-CRP >3 mg/l) and apparently had significantly higher mean hs-CRP
levels and immune parameters than patients with adequate plasma PLP
concentration. There was no significant association between plasma PLP levels and
inflammatory parameters. The significantly inverse correlation of plasma PLP with
the numbers of white blood cells, neutrophils, total lymphocytes, T lymphocytes
and T helper cells remained after adjusting for serum hemoglobin concentration,
but the significant correlation disappeared after serum albumin concentration was
also considered. Conclusions: RA patients with deficient plasma PLP concentration
had more severe inflammatory and immune responses than patients with adequate
plasma PLP concentration. However, there was a lack of association of low plasma
PLP concentration with inflammatory and immune parameters after serum albumin
concentration was considered in patients with RA.

Copyright © 2012 S. Karger AG, Basel.

PMID: 22353850 [PubMed - as supplied by publisher]