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Pilot Study on the Feasibility of PET/CT Lymphoscintigraphy with 89Zr-Nanocolloidal Albumin for Sentinel Node Identification in Oral Cancer Patients.

J Nucl Med. 2013 Feb 1;

Authors: Heuveling DA, van Schie A, Vugts DJ, Hendrikse NH, Yaqub M, Hoekstra OS, Karagozoglu KH, Leemans CR, van Dongen GA, de Bree R


With conventional imaging techniques such as planar lymphoscintigraphy and SPECT/CT, preoperative sentinel node (SN) identification can be difficult when the SN is near the primary tumor, as is the case in floor-of-mouth carcinomas. PET/CT lymphoscintigraphy may improve the detection and localization of such SNs. METHODS: In this study, the clinical feasibility of PET/CT lymphoscintigraphy using (89)Zr-nanocolloidal albumin was evaluated in 5 oral cancer patients. PET/CT lymphoscintigraphy was performed after peritumoral injection of (89)Zr-nanocolloidal albumin. The routine SN procedure, including SPECT/CT using (99m)Tc-nanocolloidal albumin, was performed on the same patients 7-9 d after the injection of (89)Zr-nanocolloidal albumin. RESULTS: Comparison of radiocolloid distribution on PET/CT and SPECT/CT showed identical drainage patterns. Moreover, PET/CT was able to identify additional foci near the primary tumor. CONCLUSION: This pilot PET/CT study on SN detection indicated that lymphoscintigraphy using (89)Zr-nanocolloidal albumin is feasible.

PMID: 23378643 [PubMed - as supplied by publisher]