albumin - publications

Predict more albumin - ligand interactions now!


1. J Pharm Sci. 2012 May 9. doi: 10.1002/jps.23181. [Epub ahead of print]

Pharmaceutical aspects of the recombinant human serum albumin dimer: Structural
characteristics, biological properties, and medical applications.

Taguchi K, Giam Chuang VT, Maruyama T, Otagiri M.

Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences,
Kumamoto University, Kumamoto 862-0973, Japan.

Human serum albumin is the most abundant protein in the blood. It is clinically
used in the treatment of severe hypoalbuminemia and as a plasma expander. The use
of albumins as a carrier for drugs is currently being developed, and some are now
in the preclinical and clinical trial stages. The main technologies for utilizing
an albumin as a drug carrier are protein fusion, polymerization and surface
modification, and so on. Among these technologies, albumin dimerization has wide
clinical applications as a plasma expander as well as a drug carrier. Despite the
fact that many reports have appeared on drugs using an albumin dimer as a
carrier, our knowledge of the characteristics of the albumin dimer itself is
incomplete. In this review, we summarize the structural characteristics of
recombinant albumin dimers produced by two methods, namely, chemical linkage with
1,6-bis(maleimido)hexane and genetically linked with an amino acid linker, and
the physicochemical characteristics and biological properties of these
preparations. Finally, the potential for pharmaceutical applications of albumin
dimers in clinical situations is discussed. © 2012 Wiley Periodicals, Inc. and
the American Pharmacists Association J Pharm Sci.

Copyright © 2012 Wiley Periodicals, Inc.

PMID: 22573538 [PubMed - as supplied by publisher]