albumin - publications

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1. Toxins (Basel). 2011 Dec;3(12):1502-17. Epub 2011 Dec 8.

Pea Albumin 1 Subunit b (PA1b), a Promising Bioinsecticide of Plant Origin.

Gressent F, Da Silva P, Eyraud V, Karaki L, Royer C.

INSA-Lyon, INRA, Université de Lyon, UMR203 BF2I, Biologie Fonctionnelle Insectes
et Interactions, Bat. Louis-Pasteur 20 av. Albert Einstein, Villeurbanne F-69621,
France; Email: Pedro.da-silva@insa-lyon.fr (P.D.S.); Vanessa.Eyraud@lyon.inra.fr
(V.E.); Lamis.Karaki@lyon.inra.fr (L.K.); Corinne.Royer@lyon.inra.fr (C.R.).

PA1b (Pea Albumin 1, subunit b) is a peptide extract from pea seeds showing
significant insecticidal activity against certain insects, such as cereal weevils
(genus Sitophilus), the mosquitoes Culex pipiens and Aedes aegyptii, and certain
species of aphids. PA1b has great potential for use on an industrial scale and
for use in organic farming: it is extracted from a common plant; it is a peptide
(and therefore suitable for transgenic applications); it can withstand many steps
of extraction and purification without losing its activity; and it is present in
a seed regularly consumed by humans and mammals without any known toxicity or
allergenicity. The potential of this peptide to limit pest damage has stimulated
research concerning its host range, its mechanism of action, its
three-dimensional structure, the natural diversity of PA1b and its
structure-function relationships.

PMCID: PMC3268454
PMID: 22295174 [PubMed - in process]