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1. Indian J Endocrinol Metab. 2012 Mar;16(2):277-82.

Pattern of urinary albumin excretion in normotensive young and adolescent Indian
women with polycystic ovary syndrome.

Ganie MA, Farooqui KJ, Bhat MA, Mir MM, Shah ZA, Douhath S, Mir SH, Rashid F,
Naqshi S, Masoodi MI, Zargar SA, Zargar AH.

Departments of Endocrinology, Nephrology, and Immunology and Molecular Medicine,
Sheri-Kashmir Institute of Medical Sciences, Soura, Srinagar, Jammu and Kashmir,

OBJECTIVE: Polycystic ovarian syndrome (PCOS) is a clinically heterogeneous
endocrine disorder affecting up to 4-8% of women of reproductive age. The aim of
this study was to evaluate the presence of microalbuminuria in women with PCOS
and study its correlation with the various metabolic, clinical, and hormonal
MATERIALS AND METHODS: A cross-sectional study involving 69 PCOS women was
carried out in a tertiary care center hospital. The diagnosis of PCOS was made
according to the Rotterdam criteria. Blood samples were collected in the
follicular phase of the menstrual cycle and analyzed for fasting luteinizing
hormone (LH), follicle stimulating hormone (FSH), prolactin (PRL),
17-hydroxyprogesterone (17-OHP), total testosterone (T), glucose, insulin, and
lipid profile. Urinary albumin was measured in the first void spot urine sample.
RESULTS: The mean age of the subjects was 22.0 ± 4.1 years and 21.8 ± 4.7 years
in normoalbuminuric and microalbuminuric groups, respectively. Urinary albumin
excretion (UAE) varied from 5 mg/l to 100 mg/ml, with a median of 5 mg/l.
Microalbuminuria was observed in 17/69 (24.6%) of subjects. The mean UAE was 3.65
± 4.44 mg/l in the normoalbuminuria group versus 45.29 ± 22.74 mg/l in the
microalbuminuria group. Upon univariate analysis, hip circumference, diastolic
blood pressure, and fasting blood glucose showed significant correlations with
urinary albumin concentration (r = 0.264, 0.264, and 0.551, respectively; P =
0.028, 0.029, and 0.000, respectively). No association between UAE and the usual
cardiovascular risk factors could be found upon regression analysis.
CONCLUSION: About 24.6% of women with PCOS showed presence of microalbuminuria in
the first void spot urine sample. Screening for the presence of microalbuminuria
can help in early identification of a subset of PCOS women with a high risk for
future CVD, who can be subjected to preventive strategies at the earliest.
However, further studies are needed before recommending routine use of UAE in
PCOS cases for the detection of CVD risk.

PMCID: PMC3313749
PMID: 22470868 [PubMed - in process]