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Parathyroid hormone, vitamin D levels, and urine albumin excretion in older persons: the 2011 Korean National Health and Nutrition Examination Survey (KNHANES).

Clin Endocrinol (Oxf). 2013 May 16;

Authors: Kim HW, Park H, Cho KH, Han K, Ko BJ


OBJECTIVE: Persistent elevation of urinary albumin excretion (UAE), even within normal range, is an independent predictor for cardiovascular disease. Accumulating research suggests that low levels of vitamin D and high levels of parathyroid hormone (PTH) also increase cardiovascular disease risk. The present study is intended to investigate the relationship between PTH, vitamin D levels, and UAE. METHODS: We examined 2897 adults aged 50 and over, participating in the second year of the fifth Korea National Health and Nutrition Examination Survey (KNHANES V-2). Anthropometric and laboratory measurements were performed. Elevated UAE was defined as spot urinary albumin creatinine ratio equal or over 10. RESULTS: The proportion of elevated UAE (21·8%, 23·2%, 23·2%, 31·8%; P for trend = 0·002) rose with increasing quartiles of PTH. The odds ratio for elevated UAE in the highest quartile of PTH was 72% higher than the lowest quartile group. There was no relationship between vitamin D and elevated UAE. CONCLUSIONS: Elevated PTH levels are associated with elevated UAE in Korean adults aged 50 and over. Additional studies are needed to clarify this relationship. This article is protected by copyright. All rights reserved.

PMID: 23679090 [PubMed - as supplied by publisher]