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1. Int J Artif Organs. 2012 Mar;35(3):226-32. doi: 10.5301/ijao.5000078.

Oxidative stress markers in hemodialysis and peritoneal dialysis patients,
including coenzyme Q10 and ischemia-modified albumin.

Mehmetoglu I, Yerlikaya FH, Kurban S, Erdem SS, Tonbul Z.

Department of Biochemistry, Meram Faculty of Medicine, University of Selcuk,
Konya - Turkey.

Objectives: Oxidative stress results from an imbalance between the production of
free radicals and antioxidant activity. There is wide agreement that patients
undergoing regular dialysis treatment experience increased oxidative stress. The
aim of this study was to investigate serum total antioxidant status (TAS), total
oxidant status (TOS), ischemia-modified albumin (IMA), and coenzyme Q10 (CoQ10)
levels in hemodialysis (HD) and continuous ambulatory peritoneal dialysis (CAPD)
patients, compared with controls. Methods: This study was performed on 41 (21
men, 20 women) CAPD patients, 38 (20 men,18 women) HD patients, and 43 (23 men,
20 women) healthy control subjects. CoQ10 levels were standardized using blood
lipids. Results: Serum TAS levels and CoQ10/total cholesterol values of the HD
and CAPD patients were significantly lower, whereas serum IMA and TOS levels were
significantly higher, than those of controls. Furthermore, CoQ10/LDL,
CoQ10/triglycerides, and CoQ10/total cholesterol + triglycerides values of the
CAPD patients were significantly lower than those of controls. No differences
were found between serum IMA, TAS, TOS, CoQ10 levels, and adjusted CoQ10 values
of the CAPD and HD patients. Conclusions: Our results suggest that oxidative
stress is increased in HD and CAPD patients compared with controls, as proven by
decreased TAS and adjusted CoQ10 levels and increased TOS and IMA levels.
Therefore, an antioxidant supplementation to these patients may be suggested.

PMID: 22461118 [PubMed - in process]