albumin - publications

Predict more albumin - ligand interactions now!


1. Biointerphases. 2012 Dec;7(1-4):5. Epub 2012 Feb 9.

Nano-sized albumin-copolymer micelles for efficient Doxorubicin delivery.

Wu Y, Shih EK, Ramanathan A, Vasudevan S, Weil T.

Institute of Organic Chemistry III, Macromolecular Chemistry,
Albert-Einstein-Allee 11, 89081, Ulm, Germany.

We present the discovery of a nano-sized protein-derived micellar drug delivery
system based on the polycationic albumin precursor protein cBSA-147. The
anticancer drug doxorubicin (DOX) was efficiently encapsulated into nanosized
micelles based on hydrophobic interactions with the polypeptide scaffold. These
micelles revealed attractive stabilities in various physiological buffers and a
wide pH range as well as very efficient uptake into A549 cells after 1 h
incubation time only. In vitro cytotoxicity was five-times increased compared to
free DOX also indicating efficient intracellular drug release. In addition,
multiple functional groups are available for further chemical modifications.
Based on the hydrophobic loading mechanism, various classical anti-cancer drugs,
in principle, could be delivered even synergistically in a single micelle.
Considering these aspects, this denatured albumin-based drug delivery system
represents a highly attractive platform for nanomedicine approaches towards
cancer therapy.

PMID: 22589048 [PubMed - in process]