albumin - publications

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IsoDGR-Tagged Albumin: A New αvβ3 Selective Carrier for Nanodrug Delivery to Tumors.


Small. 2012 Nov 12;


Authors: Curnis F, Sacchi A, Longhi R, Colombo B, Gasparri A, Corti A


Abstract

A new cyclic peptide containing the isoDGR motif that, after coupling to albumin, selectively binds αvβ3, an integrin overexpressed in the tumor vasculature. IsoDGR-tagged albumin binds tumor vessels and can be exploited as a carrier for the preparation of tumor vasculature-selective nanomedicines, such as gold nanoparticles (Au) carrying tumor necrosis factor α (TNF), a potent vascular damaging agent.

PMID: 23143930 [PubMed - as supplied by publisher]