albumin - publications

Predict more albumin - ligand interactions now!

1. Clin Biochem. 2012 Feb 9. [Epub ahead of print]

Ischemia modified albumin and carbonyl protein as potential biomarkers of protein
oxidation in hemodialysis.

Albarello K, Dos Santos GA, Bochi GV, Sangoi MB, Almeida TC, Paz da Silva JE,
Garcia SC, Moresco RN.

Programa de Pós-Graduação em Hematologia e Hemoterapia, Centro de Ciências
Biológicas, Universidade de Passo Fundo, Passo Fundo, RS, Brazil.

OBJECTIVE: The aim of this study was to evaluate the effect of HD on ischemia
modified albumin (IMA) and protein carbonyl groups in order to investigate the
role of IMA as a marker of protein oxidation. DESIGN AND METHODS: This study was
conducted with 23 chronic hemodialysis patients. The serum IMA levels and protein
carbonyl groups were measured immediately before hemodialysis (pre-HD) and after
the end of hemodialysis (post-HD). RESULTS: IMA concentrations were significantly
higher in post-HD than those of the pre-HD and carbonyl protein concentrations
were higher in post-HD in comparison with pre-HD. A significant correlation was
observed between IMA and carbonyl protein levels. CONCLUSIONS: The increase of
IMA levels and protein carbonyl groups post-HD could be attributed to the
increase of oxidative stress associated with HD, and IMA appears to be an
important biomarker for assessing protein oxidation after HD.

Copyright © 2012. Published by Elsevier Inc.

PMID: 22342921 [PubMed - as supplied by publisher]