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1. Clin Chim Acta. 2012 Feb 7. [Epub ahead of print]

Ischemia modified albumin: An oxidative stress marker in β-thalassemia major.

Awadallah SM, Atoum MF, Nimer NA, Saleh SA.

University of Sharjah, College of Health Sciences, Department of Medical Lab
Sciences, Sharjah, United Arab Emirates.

BACKGROUND: Ischemia modified albumin (IMA) is an altered type of serum albumin
that forms under conditions of oxidative stress. This study reports on the levels
and clinical significance of IMA in patients with β-thalassemia major. METHODS:
Blood specimens were collected from 166 subjects (101 β-thalassemia major
patients and 65 healthy controls). Serum levels of IMA, ferritin, malondialdehyde
(MDA), ferroxidase, transaminases, total protein, and albumin were determined
using conventional methods. RESULTS: Serum levels of IMA (ABSU) were
significantly higher in patients than in controls (0.725±0.155 vs 0.554±0.154,
p=0.000). Similarly, higher levels were also observed for ferritin, MDA,
ferroxidase, and transaminases. No significant differences were observed between
patients and controls with respect to total protein and albumin. Spearman
univariate analysis demonstrated significant correlation between IMA and
ferritin, MDA, ferroxidase, and transaminases. Multiple linear regression
analysis revealed significant association of IMA with ferritin and ferroxidase
after adjusting for the other variables (r=0.343, p=0.002; r=0.228, p=0.029
respectively). MDA however, correlated significantly with ferritin only (r=0.654,
p=0.000). CONCLUSION: Our findings suggest that increased levels of IMA in
thalassemic patients are likely to be a result of iron-induced oxidative stress
and hence its potential significance as a new marker of oxidative stress in such
patients.

Copyright © 2012. Published by Elsevier B.V.

PMID: 22336636 [PubMed - as supplied by publisher]