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Ischemia-modified albumin, a predictive marker of major adverse cardiovascular events in continuous ambulatory peritoneal dialysis patients.


Clin Biochem. 2013 Jun 21;


Authors: Su X, Zhang K, Guo F, Yuan B, Wang C, Xiao L, Wang J, Huang H


Abstract

OBJECTIVES: The aim of this study was to evaluate the efficiency of ischemia-modified albumin (IMA) for predicting major adverse cardiovascular events (MACE) in continuous ambulatory peritoneal dialysis (CAPD) patients.

DESIGN AND METHODS: A prospective observational study was conducted with 120 CAPD patients and 37 healthy volunteers. Demographic and clinical data were collected. The primary end point is occurrence of MACE.

RESULTS: A total of 157 participants with a mean age of 43.64 years finally complete this study. The CAPD patients had a significant high rate of MACE (P = 0.001) and high levels of IMA than healthy controls (P < 0.001). Compared with CAPD patients with normal levels of IMA, the CAPD patients with high levels of IMA (> 85 KU/L) had lower non-MACE survival rate (P < 0.001), which indicated that the high IMA CAPD patients may suffer a high rate of MACE. In addition, the high IMA CAPD patients also had a low level of serum albumin (P < 0.001) and hemoglobin (P = 0.018). The correlation analysis showed that the serum albumin level was the most effective factor influencing IMA (B = -0.967, P < 0.001).

CONCLUSIONS: CAPD patients with high levels of IMA had a high incidence rate of MACE. IMA was a good predictive marker of MACE and might be important in cardiovascular risk stratification of CAPD patients.

PMID: 23796881 [PubMed - as supplied by publisher]