albumin - publications

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1. Appl Phys Lett. 2012 Jan 2;100(1):13703-137034. Epub 2012 Jan 5.

Interaction of lipid vesicle with silver nanoparticle-serum albumin protein
corona.

Chen R, Choudhary P, Schurr RN, Bhattacharya P, Brown JM, Chun Ke P.

The physical interaction between a lipid vesicle and a silver nanoparticle
(AgNP)-human serum albumin (HSA) protein "corona" has been examined.
Specifically, the binding of AgNPs and HSA was analyzed by spectrophotometry, and
the induced conformational changes of the HSA were inferred from circular
dichroism spectroscopy. The fluidity of the vesicle, a model system for mimicking
cell membrane, was found to increase with the increased exposure to AgNP-HSA
corona, though less pronounced compared to that induced by AgNPs alone. This
study offers additional information for understanding the role of physical forces
in nanoparticle-cell interaction and has implications for nanomedicine and
nanotoxicology.

PMID: 22271932 [PubMed]