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Influence of pretreatment ideal body weight percentile and albumin on the prognosis of nasopharyngeal carcinoma: Long-term outcomes of 512 patients from a single institution.

Head Neck. 2013 Apr 22;

Authors: Li G, Gao J, Liu ZG, Tao YL, Xu BQ, Tu ZW, Zhang XP, Zeng MS, Xia YF


Background: This study was to investigate the relationship between pretreatment nutritional status and prognosis of nasopharyngeal carcinoma (NPC). Methods: Pretreatment nutritional status was evaluated by ideal body weight percentile (IBW %) and serum albumin for 512 NPC patients received radical radiotherapy. Kaplan-Meier methods, log-rank test, and a Cox model were applied for survival analysis. Results: Before radiotherapy, IBW% < 90% was related to poorer overall survival (OS) and distant metastasis free survival (DMFS) (P=0.031, P = 0.012); albumin ≤ 43.0 g/ L was related to poorer OS and DMFS (P < 0.001, P = 0.042); both IBW% and albumin were independent prognostic factors for OS; those patients with IBW% < 90% and albumin ≤ 43.0 g/ L simultaneously had the worst OS and DMFS. Conclusions: Decrease of pretreatment IBW% and albumin was related to poorer survival of NPC. Head Neck, 2013.

PMID: 23606535 [PubMed - as supplied by publisher]