albumin - publications

Predict more albumin - ligand interactions now!


1. Neoplasma. 2012 Apr 10. doi: 10.4149/neo_2012_051. [Epub ahead of print]

Increased ischemia-modified albumin levels in patients with gastric cancer.

Fidan E, Mentese A, Kavgaci H, Orem A, Fidan S, Uzun A, Ozdemir F, Aydin F.

Reactive oxygen species (ROS) are found in the development stages of
carcinogenesis.Fifty two patients with gastric cancer and 35 controls were
enrolled in this trial. IMA, MDA, Total Oxidant Status (TOS), Total Antioxidant
Status (TAS) and Oxidative Stress Index (OSI) were evaluated. There was
a significant increase in IMA and MDA levels in the patient group (0.405±0.111,
0.271±0.066; p= 0.0001 and 0.207±0.251, 0.077±0.103; p= 0.004 respectively). TOS
was also higher in the patient group but it was not statistically different. TAS
was statistically lower and there was significant difference in OSI (0.621±0.394,
0.996±0.37; p=0.0001 and 9.68±18.2, 2.9±3.85; p=0.001 respectively). The areas
under receiver operating characteristics curves for the determination of gastric
cancer were 0.842 for IMA and 0.708 for MDA. Increased levels of IMA, MDA and
oxidative stress index were detected and this condition is associated with the
impairment of oxidant-antioxidant balance. Keywords: ischemia modified albumin,
gastric cancer, oxidative stress.

PMID: 22489694 [PubMed - as supplied by publisher]