albumin - publications

Predict more albumin - ligand interactions now!


1. Curr Pharm Des. 2012 Jan 17. [Epub ahead of print]

Human Serum Albumin Conjugated Biomolecules for Cancer Molecular Imaging.

Yang M, Hoppmann S, Chen L, Cheng Z.

Molecular Imaging Program at Stanford, Department of Radiology and Bio-X Program,
Canary Center at Stanford for Cancer Early Detection, 1201 Welch Road, Lucas
Expansion, P095 Stanford University Stanford, CA 94305 Email:
zcheng@stanford.edu.

Molecular imaging is a fast growing field in biomedical research. The discovery,
development and continual improvement of molecular probes are important for
ongoing research efforts in molecular imaging. Human serum albumin (HSA) offers
favorable characteristics and opportunities as a platform protein for molecular
imaging probe discovery and optimization. It has many advantages, including
alternation of biodistribution and pharmacokinetic properties of molecular
imaging probes, enhancing the blood half-life of biomolecules, and making these
molecules multivalent, all of which make HSA a promising carrier for cancer-
targeted imaging and therapy. Numerous studies have focused on the development
and application of HSA-based cancer imaging and treatment. This review gives a
brief account of albumin-based molecular probes, focusing on their applications
in cancer molecular imaging, such as PET/SPECT, MRI and optical imaging.

PMID: 22272822 [PubMed - as supplied by publisher]