albumin - publications
Human serum albumin can regulate Amyloid-beta peptide fiber growth in the brain interstitium. Implications for Alzheimer's Disease.
J Biol Chem. 2012 Jun 20;
Authors: Stanyon HF, Viles JH
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by extracellular accumulation of amyloid-beta peptide (AÃÂ²) in the brain interstitium. Human serum albumin (HSA) binds 95 % of AÃÂ² in blood plasma and is thought to inhibit plaque formation in peripheral tissue. However, albumin's role in binding AÃÂ² in the cerebrospinal fluid (CSF) has been largely overlooked. Here we investigate the effect of HSA on both AÃÂ²(1-40) and AÃÂ²(1-42) fibril growth. We show that at micromolar CSF levels, HSA inhibits the kinetics of AÃÂ² fibrillization, significantly increasing the lag-time and decreasing the total amount of fibrils produced. Furthermore we show that the amount of amyloid fibers generated directly correlates to the proportion of AÃÂ² not competitively bound to albumin. Our observations suggest a significant role for HSA regulating AÃÂ² fibril growth in the brain interstitium.
PMID: 22718756 [PubMed - as supplied by publisher]