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Human Serum Albumin-Based Peroxidase Having an Iron Protoporphyrin IX in Artificial Heme Pocket.


Chem Asian J. 2012 Aug 21;


Authors: Watanabe K, Ishikawa N, Komatsu T


Abstract

Cooking up enzymes: Iron protoporphyrin IX (heme) is bound within a hydrophobic cavity in subdomain IB of human serum albumin (HSA). Site-specific mutations to introduce proximal and distal histidines into the heme pocket of HSA conferred a peroxidase activity to the prosthetic heme group. The catalytic activity of the recombinant HSA(mutant)-heme complex for guaiacol oxidation is 17-fold higher than that of HSA(wild type)-heme.

PMID: 22907927 [PubMed - as supplied by publisher]