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Hsa-miR-196a2 Functional SNP is Associated With Severe Toxicity After Platinum-Based Chemotherapy of Advanced Nonsmall Cell Lung Cancer Patients in a Chinese Population.


J Clin Lab Anal. 2012 Nov;26(6):441-6


Authors: Zhan X, Wu W, Han B, Gao G, Qiao R, Lv J, Zhang S, Zhang W, Fan W, Chen H, Zhang T, Gu A, Shen J, Wu Q, Lu D


Abstract

BACKGROUND: Rs11614913 is a polymorphism in hsa-miR-196a2 reported to alter mature microRNA expression and function. This single-nucleotide polymorphism (SNP) was reported to be associated with susceptibility and prognosis of lung cancer.

METHODS: In this article, association study was performed to reveal the relation between SNP and response rate or severe toxicity after platinum-based regimen in advanced nonsmall cell lung cancer patients.

RESULTS: By screening this polymorphism in 442 Chinese patients with MALDI-TOF Mass Spectrometer, significantly higher occurrence of grade 3 or 4 overall toxicity (P = 0.02) in response to treatment was found in patients with homozygous CC. After stratified analyses, association between rs11614912 and overall toxicity existed, especially in individuals treated with gemcitabine (P = 0.006) or cisplatin (P = 0.008), and in male patients (P = 0.02) or younger patients (P = 0.01).

CONCLUSION: Our study confirmed that rs11614913 in hsa-miR-196a2 was associated with severe toxicity in lung cancer patients, and might help to improve individualized therapy in the future.

PMID: 23143626 [PubMed - in process]