albumin - publications

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1. Horm Res Paediatr. 2012 Apr 26. [Epub ahead of print]

Glycated Albumin in Patients with Neonatal Diabetes Mellitus Is Apparently Low in
Relation to Glycemia Compared with That in Patients with Type 1 Diabetes

Suzuki S, Koga M, Takahashi H, Matsuo K, Tanahashi Y, Azuma H.

Department of Pediatrics, Asahikawa Medical University, Asahikawa, Japan.

Background: Although glycated albumin (GA) is a useful glycemic control marker in
neonatal diabetes mellitus (NDM), there has been no report comparing GA levels
between NDM patients and non-diabetic infants. Moreover, GA in NDM patients may
be apparently low in relation to glycemia due to the assumed elevation of albumin
metabolism in neonates. Methods: We compared GA levels between 6 patients with
NDM and 18 non-diabetic infants or 14 patients with type 1 diabetes mellitus
(T1DM). Mean blood glucose (MBG) was calculated on the basis of self-monitoring
of blood glucose for 1 month before GA measurement. Results: GA in NDM patients
was significantly higher than that in non-diabetic infants (22.0 ± 5.8 vs. 10.2 ±
1.4%; p < 0.0001), and GA levels significantly correlated with MBG in both NDM
and T1DM patients. However, GA in NDM patients was significantly lower than in
T1DM patients (25.8 ± 5.3%; p = 0.0046), whereas MBG in NDM patients was
significantly higher than in T1DM patients (233 ± 79 vs. 183 ± 41 mg/dl; p =
0.0006). Conclusion: GA levels in NDM patients were apparently low in relation to
glycemia. Therefore, reference values for infants should be used for assessing
the GA level in NDM.

Copyright © 2012 S. Karger AG, Basel.

PMID: 22538993 [PubMed - as supplied by publisher]