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[Fluorescence spectroscopic study on the biointeraction of new organometallic carborane derivatives with bovine serum albumin].


Guang Pu Xue Yu Guang Pu Fen Xi. 2013 Jan;33(1):120-5


Authors: Wu CH, Ye HD, Wu DH, Yan H, Wang XM, Chen J


Abstract

The biointeractions between a series of new organometallic carborane derivatives and model protein bovine serum albumin (BSA) were investigated by means of fluorescence and synchronous spectroscopy. The observations demonstrate that the ferrocene-carborane conjugates (FcSB1, FcSB2 and FcSBCO) and the ruthenium(II)-arene carborane complexes (RuBFc and RuBCOOH) can form a steady complex with BSA and statically quench its fluorescence. The ferrocene-carborane conjugates could remarkably affect the tertiary structure of BSA and induce the microenvironment changes of Trp and Tyr residues from hydrophilic to hydrophobic environment. But the effect of the ruthenium(II)-arene carborane complexes on the tertiary structure of BSA is much less. This study would give meaningful insights into the evaluation of the promising biomedical applications of the new carborane derivatives and benefit the development of potential multifunctional metallodrugs.

PMID: 23586239 [PubMed - in process]