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1. Calcif Tissue Int. 2012 Jan 22. [Epub ahead of print]

Femoral Neck Bone Strength Estimated by Hip Structural Analysis (HSA) in Swedish
Caucasians Aged 6-90 Years.

Alwis G, Karlsson C, Stenevi-Lundgren S, Rosengren BE, Karlsson MK.

Clinical and Molecular Osteoporosis Research Unit, Department of Orthopedics and
Clinical Sciences, Lund University, Skåne University Hospital, 205 02, Malmö,

Dual-energy X-ray absorptiometry hip scans of 1,760 population-based Caucasians,
599 girls and 642 boys aged 6-19 years and 270 women and 249 men aged
20-90 years, were analyzed with the hip structural analysis (HSA) software to
present age- and sex-specific normative HSA data of the femoral neck (FN).
Measured traits included bone mineral density (BMD), cross-sectional area (CSA),
section modulus (Z), periosteal diameter (PD), endosteal diameter (ED), cortical
thickness (CT), and cross-sectional moment of inertia (CSMI). When plotting the
measured traits versus age, the curves increased with higher ages until
statistically significant break points were reached, for all traits at age 17 in
girls and age 19 in boys. After the break points, PD and ED increased with higher
ages but, as ED increased more than PD, BMD and CT decreased significantly with
higher ages. The decline in BMD was counteracted by the increase in bone size so
that there was only a nonstatistically significant decrease in bone strength,
estimated as Z and CSMI, from break point to age 90. The partial preservation of
bone strength was more obvious in men than in women as the decline in BMD was
higher in women than in men, while the expansion in PD was larger in men than in
women. The sex difference in the normative FN bone strength data seems to be
related to sex discrepancies in the development of both bone mass and geometrical
parameters during both growth and adulthood.

PMID: 22271247 [PubMed - as supplied by publisher]