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1. Nan Fang Yi Ke Da Xue Xue Bao. 2012 Feb;32(2):198-201.

[Expression of hsa-miR-20a in human glioma tissues and its effect on the
proliferation of human glioma cells in vitro].

[Article in Chinese]

Yao X, Li W, Wang Y, Ding Z, Hou W, Zeng M, Deng G, Zhang J, Yang H.

Department of Neurosurgery, Qingyuan People's Hospital, Qingyuan 511518, China.
E-mail: jluyy@126.com.

OBJECTIVE: To investigate miR-20a expression in human glioma and normal brain
tissues and its effect on the proliferation of glioma cells in vitro.
METHODS: The expression of miR-20a was detected in human normal brain tissues and
glioma tissues by real-time RT-PCR. miR-20a mimics were synthesized and
transfected into U251 cells via liposome, and the cell proliferation were
detected using MTT assay and flow cytometry.
RESULTS: The glioma tissues showed significantly up-regulated expression of
miR-20a compared with normal brain tissues (P=0.035). The expression level of
miR-20a was higher in high-grade than in low-grade gliomas. miR-20a mimics
significantly enhanced the proliferation of U251 cells and the percentage of
S-phase cells.
CONCLUSION: miR-20a shows potent effect in promoting the growth of glioma cells,
suggesting its important role in the pathogenesis of human glioma.

PMID: 22381757 [PubMed - in process]