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Explaining the Highly Enantiomeric Photocyclodimerization of 2-Anthracenecarboxylate Bound to Human Serum Albumin using Time-resolved Anisotropy Studies.

J Am Chem Soc. 2012 Dec 13;

Authors: Fuentealba D, Kato H, Nishijima M, Fukuhara G, Mori T, Inoue Y, Bohne C


The mechanism for the high enantiomeric excess (ee) (80-90%) observed in the photocyclodimerization of 2-anthracenecarboxylate (AC) in the chiral binding sites of human serum albumin was studied using fluorescence anisotropy. A long rotational correlation time of 36 ns was observed for the excited states of the ACs bound to the HSA site responsible for the high ee, suggesting that the ACs have restricted rotational mobility in this site. The ACs in this site have the same prochiral face pro-tected by the protein and this protection is responsible for the high ee observed. These insights provide a strategy for the ra-tional design of supramolecular photochirogenic systems.

PMID: 23237511 [PubMed - as supplied by publisher]