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1. Gynecol Endocrinol. 2012 May 10. [Epub ahead of print]

Evaluation of serum ischemia-modified albumin levels in pregnant women with and
without gestational diabetes mellitus.

Ma SG, Yu WN, Jin Y, Hong B, Hu W.

Department of Endocrinology and Metabolism , Huai'an , China.

Objective. To investigate serum ischemia-modified albumin (IMA) levels in
gestational diabetes mellitus and the effect of treatment with continuous
subcutaneous insulin infusion on the biomarker. Methods. The gestational diabetes
mellitus women in the second trimester were evaluated before and after the two
kinds of treatments with continuous subcutaneous insulin infusion and medical
nutrition therapy for 6 weeks. Maternal serum ischemia-modified albumin and
metabolic parameters were measured at baseline and at the 6th week. Results.Serum
ischemia-modified albumin levels and metabolic parameters were higher in patients
with gestational diabetes mellitus at baseline than in controls.
Ischemia-modified albumin levels were correlated with plasma glucose (p < 0.05).
Variables of glycemic control and ischemia-modified albumin levels were
significantly reduced at the 6th week. The effect of insulin treatment was
generally better than diet therapy. Linear regression analysis showed that
fasting plasma glucose was an independent determinant for IMA levels (β = 0.611,
p = 0.035).Fetal outcome was similar except for macrosomia and Apgar score at 5
min. Conclusion.Serum ischemia-modified albumin levels were higher in gestational
diabetes mellitus compared to normal pregnancy. Continuous subcutaneous insulin
infusion consistently improved metabolic disorder control. Gestational diabetes
mellitus women were associated to a higher risk of oxidative stress and pregnancy
complications.

PMID: 22571721 [PubMed - as supplied by publisher]