albumin - publications

Predict more albumin - ligand interactions now!


1. BMC Nephrol. 2012 May 7;13(1):26. [Epub ahead of print]

Ethnic differences in the association between waist-to-height ratio and
albumin-creatinine ratio: the observational SUNSET study.

van Valkengoed IG, Agyemang C, Krediet RT, Stronks K.

ABSTRACT: BACKGROUND: Ethnic differences in the association between central
obesity and raised albumin-creatinine ratio (ACR) have not been investigated. Our
aim was to determine whether the association between central obesity, defined by
the waist-to-height ratio (WHtR), and ACR differed between subjects of
Hindustani-Surinamese, African-Surinamese and Dutch origin. METHODS: In total,
334 Hindustani-Surinamese (~South Asian), 589 African-Surinamese (~African), and
493 Dutch (~European) men and women, aged 35-60 years, randomly selected from the
municipal register of Amsterdam, participated in an interview and physical
examination. We calculated the WHtR by dividing the waist circumference by height
and the log ACR (logACR, log mg/mmol) by log-transforming the albumin
concentration by the creatinine concentration in urine. The association between
WHtR and logACR was studied in the total population and stratified by ethnicity.
We also tested for interaction. RESULTS: In the total population, a higher WHtR
was associated with a higher logACR, after adjustment for sex, age, and smoking,
body mass index and the presence of type 2 diabetes or hypertension. Among the
Hindustani-Surinamese, the adjusted association between WHtR and logACR appeared
somewhat stronger than among the other ethnic groups: for every 0.1 increase in
the WHtR, the log-ACR increased by 0.522 (0.096-0.949) log mg/mmol among the
Hindustani-Surinamese, by 0.334 (0.047-0.622) among the African-Surinamese and by
0.356 (0.010-0.721) among the Dutch. However, the interaction was not
statistically significant. CONCLUSIONS: WHtR was associated with a higher ACR
among populations of Hindustani-Surinamese, African-Surinamese and Dutch origin.
Our study seems to support global use of WHtR in relation to ACR across ethnic
groups. However, although not significant, the association appeared slightly
stronger among the Hindustani-Surinamese than among the other ethnic groups. If
confirmed, this could have implications for use of the WHtR across ethnic groups.

PMID: 22564356 [PubMed - as supplied by publisher]