albumin - publications

Predict more albumin - ligand interactions now!

1. Yonsei Med J. 2012 May 1;53(3):578-86. doi: 10.3349/ymj.2012.53.3.578.

Estimating average glucose levels from glycated albumin in patients with
end-stage renal disease.

Kim JK, Park JT, Oh HJ, Yoo DE, Kim SJ, Han SH, Kang SW, Choi KH, Yoo TH.

Department of Internal Medicine, Yonsei University College of Medicine, 50
Yonsei-ro, Seodaemun-gu, Seoul 120-752, Korea.

Purpose: In patients with diabetic end stage renal disease (ESRD), glycated
albumin (GA) reflects recent glycemic control more accurately than glycated
hemoglobin (HbA1c). We evaluated the relationship between GA and average blood
glucose (AG) level and developed an estimating equation for translating GA values
into easier-to-understand AG levels. Materials and Methods: A total of 185 ESRD
patients, including 154 diabetic and 31 non-diabetic participants, were enrolled
(108 hemodialysis, 77 peritoneal dialysis). Patients were asked to perform
four-point daily self-monitoring of capillary blood glucose (SMBG) at least three
consecutive days each week for four weeks. Serum levels of GA, HbA1c and other
biochemical parameters were checked at baseline, as well as at 4 and 8 weeks.
Results: Approximately 74.3±7.0 SMBG readings were obtained from each participant
and mean AG was 169.1±48.2 mg/dL. The correlation coefficient between serum GA
and AG levels (r=0.70, p<0.001) was higher than that of HbA1c and AG (r=0.54,
p<0.001). Linear regression analysis yielded the following equation: estimated AG
(eAG) (mg/dL)=4.71×GA%+73.35, and with this formula, serum GA levels could be
easily translated to eAG levels. Multivariate analysis revealed significant
contributions of postprandial hyperglycemia (β=0.25, p=0.03) and serum albumin
(β=0.17, p=0.04) in determining serum GA level, independent to other clinical
parameters. Conclusion: Compared to HbA1c, serum GA levels were better correlated
with AG levels. Using the estimating equation, an average blood glucose level of
155-160 mg/dL could be matched to a GA value of 18-19% in patients with ESRD.

PMID: 22477003 [PubMed - in process]