albumin - publications

Predict more albumin - ligand interactions now!


1. J Mater Sci Mater Med. 2012 Mar 10. [Epub ahead of print]

Effect of protein concentrations of bovine serum albumin and γ-globulin on the
frictional response of a cobalt-chromium femoral head.

Duong CT, Lee JH, Cho Y, Nam JS, Kim HN, Lee SS, Park S.

School of Mechanical Engineering & Institute for Skeletal Aging, Pusan National
University, Busan, Republic of Korea.

The study aims to identify the concentration-dependent role of bovine serum
albumin (BSA) and γ-globulin in the lubricating ability of a cobalt-chromium
femoral head. The frictional coefficients of the cobalt-chromium femoral head
decreased with increasing BSA concentrations from 10 to 40 mg/ml and showed
statistical differences between any of the BSA concentration groups, except
between the 30 and 40 mg/ml concentration groups. In γ-globulin, the frictional
coefficients significantly decreased at concentrations of 2.5 and 5.0 mg/ml as
compared with the PBS control group, but significant increases were observed at
7.5 and 12.5 mg/ml. These results suggest that the friction of the
cobalt-chromium femoral head is dependent on the concentration of both BSA and
γ-globulin. However, there is a maximum concentration for BSA to act as an
effective boundary lubricant, while the lubricating ability of γ-globulin is most
effective in the physiological concentration range within human synovial fluid.

PMID: 22407001 [PubMed - as supplied by publisher]