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1. Diabet Med. 2012 Jan 24. doi: 10.1111/j.1464-5491.2012.03593.x. [Epub ahead of
print]

Comparison of renal resistive index among patients with Type 2 diabetes with
different levels of creatinine clearance and urinary albumin excretion.

Afsar B, Elsurer R.

Department of Nephrology, Konya Numune State Hospital, Konya Department of
Nephrology, Faculty of Medicine, Selcuk University, Selçuklu, Turkey.

Aim:  To evaluate the prevalence of increased renal resistive index and related
factors among patients with Type 2 diabetes with different levels of creatinine
clearance and urinary albumin excretion. Methods:  Laboratory analyses, including
calculation of 24-h urinary albumin excretion and 24-h creatinine clearance, and
renal doppler ultrasonography to measure renal resistive index, were carried out
for patients newly diagnosed with Type 2 diabetes mellitus. Results: 
Participants were classified into four groups according to 24-h creatinine
clearance and 24-h urinary albumin excretion levels. Group 1 was composed of 73
patients (54.1%) with normal 24-h creatinine clearance and 24-h urinary albumin
excretion. Group 2 was composed of 34 (25.2%) patients with normal 24-h
creatinine clearance and increased 24-h urinary albumin excretion. Group 3 was
composed of 14 (10.4%) patients with decreased 24-h creatinine clearance and
normal 24-h urinary albumin excretion. Group 4 was composed of 14 (10.4%)
patients with both decreased 24-h creatinine clearance and increased 24-h urinary
albumin excretion. In total, 41 patients (30.4%) had increased renal resistive
index levels. Comparison of the four groups with respect to increased renal
resistive index revealed: among group 1 patients, 10 (13.7%) had increased renal
resistive index levels; among group 2 patients, 14 (41.2%) had increased renal
resistive index levels; among group 3 patients, eight (57.1%) had increased renal
resistive index levels; among group 4 patients, nine (64.3%) had increased renal
resistive index levels (P < 0.0001 for trend). In multivariate regression, 24-h
creatinine clearance (P < 0.0001), but not 24-h urinary albumin excretion, was
related to increased renal resistive index levels. Conclusion:  Renal resistive
index levels were highest in patients with Type 2 diabetes with both decreased
24-h creatinine clearance and increased 24-h urinary albumin excretion, whereas
they were lowest in patients with normal creatinine clearance and normal urinary
albumin excretion. © 2012 The Authors. Diabetic Medicine © 2012 Diabetes UK.

© 2012 The Authors. Diabetic Medicine © 2012 Diabetes UK.

PMID: 22269249 [PubMed - as supplied by publisher]