albumin - publications

Predict more albumin - ligand interactions now!


1. Chem Asian J. 2012 Apr 13. doi: 10.1002/asia.201100954. [Epub ahead of print]

Calcium Phosphate Nanocarriers Dual-Loaded with Bovine Serum Albumin and
Ibuprofen: Facile Synthesis, Sequential Drug Loading and Sustained Drug Release.

Zhao XY, Zhu YJ, Chen F, Wu J.

State Key Laboratory of High Performance Ceramics and Superfine Microstructure,
Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050
(P.R. China), Fax: (+86) 21-52413122.

A simple and green strategy is reported for the preparation, drug loading, and
release properties of a drug delivery system consisting of calcium phosphate (CP)
nanocarriers dual-loaded with bovine serum albumin (BSA) and hydrophobic drug
ibuprofen (IBU). The sequential loading of BSA and IBU in calcium phosphate
nanocarriers and in vitro simultaneous release of BSA and IBU are realized and
investigated. In this method, BSA, which is used as a model protein drug, is
encapsulated in situ in calcium phosphate nanocarriers. Subsequently, the typical
hydrophobic drug IBU is loaded in the BSA/CP drug delivery system, forming the
IBU/BSA/CP dual drug delivery system. The experiments reveal that the preloaded
BSA not only reduces the cytotoxicity of calcium phosphate nanocarriers but also
significantly improves the IBU drug loading capacity in calcium phosphate
nanocarriers and greatly extends the duration of drug release. Thus, the
as-prepared IBU/BSA/CP dual drug delivery system is promising for drug delivery
applications.

Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

PMID: 22504936 [PubMed - as supplied by publisher]