albumin - publications

Predict more albumin - ligand interactions now!

1. Anticancer Agents Med Chem. 2012 Jan 31. [Epub ahead of print]

Bovine Serum Albumin Significantly Improves The DPPH Free Radical Scavenging
Potential Of Dietary Polyphenols And Gallic Acids.

Cao H, Chen X, Yamamoto K.

Department of Nutrition, Faculty of Health and Welfare, Okayama Prefectural
University, Kuboki 111, Soja, Okayama 719-1197, Japan.

The polyphenols-protein interaction is reversible in that the polyphenols-protein
complex can dissociate and release the free polyphenols. The aim of this study is
to evaluate the contribution of polyphenol-protein interactions (PPI) on
improving the DPPH radical scavenging capacity of polyphenols. The DPPH radical
scavenging potential of polyphenols was determined from 1 to 7 days under aerobic
condition. The DPPH radical scavenging capacity of polyphenols depended on the
structures of dietary polyphenols and gallic acids. The DPPH radical scavenging
percentages of H-group polyphenols were weakened when kept in room temperature
from 1 to 7 days. BSA rapid weakened the DPPH radical scavenging activity of
polyphenols on the first day. However, the DPPH scavenging capacities of
polyphenols in the presence of BSA overwhelmingly improved with increasing time.
These results illustrated that BSA not only prolongs the effective time, but also
improved the DPPH radical scavenging potential of polyphenols. The increasing
DPPH scavenging percentages of polyphenols were slightly decreased with increased
affinities of BSA-polyphenol complexes.

PMID: 22292770 [PubMed - as supplied by publisher]