albumin - publications

Predict more albumin - ligand interactions now!


1. J Nanosci Nanotechnol. 2011 Dec;11(12):11074-8.

Binding studies of L-tryptophan to human serum albumin with nanogold-structured
sensor by piezoelectric quartz crystal impedance analysis.

Long Y, Yao S, Chen J.

College of Chemistry, Chemical Engineering and Materials Science, Soochow
University, Suzhou 215123, PR China.

Nanogold-modified sensor was constructed and applied to study the binding of
L-tryptophan to human serum albumin (HSA) in situ by piezoelectric quartz crystal
impedance (PQCI) analysis. It was interesting that the as-prepared nanogold
modified sensor was more sensitive and biocompatible than bare gold electrode.
The frequency changes due to protein adsorption on the nanogold-modified sensor
might be described as a sum of two exponential functions and detailed explanation
was given. Additionally, the kinetics of the binding process was also
investigated. The binding constant (K) and the number of binding site (n) for the
binding process without competitor are fitted to be 1.07 x 10(4) (mol l(-1))(-1)
s(-1) and 1.13, respectively, and 2.24 x 10(3) (mol l-(1))(-1) s(-1) and 1.18,
respectively for the binding process with competitor.

PMID: 22409059 [PubMed - in process]