albumin - publications

Predict more albumin - ligand interactions now!

1. Spectrochim Acta A Mol Biomol Spectrosc. 2012 Mar 15;93C:180-184. [Epub ahead of

Binding interaction of 1-(4-methybenzyl)-2-p-tolyl-1H-benzo[d]imidazole with
bovine serum albumin.

Jayabharathi J, Thanikachalam V, Jayamoorthy K, Srinivasan N.

Department of Chemistry, Annamalai University, Annamalainagar, Tamilnadu 608002,

A promising benzimidazole derivative
1-(4-methybenzyl)-2-p-tolyl-1H-benzo[d]imidazole (MBTBI) has been synthesized and
characterized by single crystal XRD, NMR, mass and IR spectral techniques. The
mutual interaction of this benzimidazole derivative (MBTBI) with bovine serum
albumin (BSA) was investigated using solution spectral studies. The fluorescence
quenching mechanism of BSA by MBTBI was analyzed and the binding constant has
been calculated. The binding distance between these two was obtained based on the
theory of Forester's non-radiation energy transfer (FRET). The effect of some
common ions on the binding constant was also examined.

Copyright © 2012 Elsevier B.V. All rights reserved.

PMID: 22481174 [PubMed - as supplied by publisher]